Alterning chemical modifications of DNA lets the DNA from two sperm make a mouse.
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Researchers get viable mice by editing DNA from two sperm
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We're most certainly a ways off from it, even if it is possible, both from an international legislation standpoint, and from an implementation standpoint, but this has really fucking cool implications for homosexuals who want natural born children.
Only real solution for it that I'm aware of today is for one partner to have the other partner's opposite sex sibling's sperm/egg implanted with their egg/sperm in a surrogate(unless the sibling can and does volunteer to be the surrogate momma), which is hideously expensive, and doesn't quite result in true biological children.
Only real solution for it that I'm aware of today is for one partner to have the other partner's opposite sex sibling's sperm/egg implanted with their egg/sperm in a surrogate(unless the sibling can and does volunteer to be the surrogate momma), which is hideously expensive, and doesn't quite result in true biological children.
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With this technology, we will have the perfect set up for a rom-com... <roll trailer>
Adam and Steve are finally going to settle down and, thanks to advances in technology, have a baby together, just like they always dreamed! But imagine their surprise when... it's a girl!
Cut to...
Adam: I think she looks like you.
Steve: No, more like you, I think.
Adam: Actually, she kinda reminds me of... your mother!
Laugh Track: Uproarious Hilarity
Steve: Oh Adam! /cheesy smile
Coming this Summer! </trailer>
Adam and Steve are finally going to settle down and, thanks to advances in technology, have a baby together, just like they always dreamed! But imagine their surprise when... it's a girl!
Cut to...
Adam: I think she looks like you.
Steve: No, more like you, I think.
Adam: Actually, she kinda reminds me of... your mother!
Laugh Track: Uproarious Hilarity
Steve: Oh Adam! /cheesy smile
Coming this Summer! </trailer>
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Natural born children? Well... no. They had to do lots of gene editing to even get the offspring to survive into adulthood. And these are mice. But I agree it has interesting implications. I just can't imagine it actually being done on humans for a very, very long time and after many years of research.
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Thank you for the coverage of this interesting subject matter, John. A couple editing notes for the article:
Typo in subtitle of article.
This is an incomplete sentence.
After noticing both of these issues while reading the article, I paused and (out of curiosity) decided to paste the full article into ChatGPT, prompting it to call out any grammar issues. It found both issues I mentioned, along with a short list of other grammar notes. If there's one use of AI that I suppose I can really get behind, it's helping catch writing errors.
Thank you again.
Typo in subtitle of article.
This is an incomplete sentence.
After noticing both of these issues while reading the article, I paused and (out of curiosity) decided to paste the full article into ChatGPT, prompting it to call out any grammar issues. It found both issues I mentioned, along with a short list of other grammar notes. If there's one use of AI that I suppose I can really get behind, it's helping catch writing errors.
Thank you again.
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Going by the headline, sub, and first half of the article, I was under the impression this was done without an egg, which I thought was most impressive.
But, it still requires an egg. Still interesting, but somehow less so.
But, it still requires an egg. Still interesting, but somehow less so.
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The problem you're gonna run into is, how to create a functional synthetic egg?
It's relatively trivial, by comparison, to implant new DNA into an existing egg.
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That's what I meant. I was looking forward to the "no egg at all required" explanation. Anyway, just a misunderstanding.
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Half the sperm have an X chromosome, the other half have a Y, of course. I imagine they get paired up randomly. The embryos that have two Y's don't live.
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Not really worth the effort of making artificial eggs. Plenty of eggs never get used so offering a reasonable price for them, with the understanding the DNA in the eggs will not be used, will be MUCH easier(read BILLION OF DOLLARS CHEAPER).
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I get the how but not the why. Honestly it seems I don't understand the first paragraph. Males who want as many offspring as possible with mothers giving their all vs females who want to maximize what every offspring gets. No. I don't get what the fight is for.
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I wonder how many narcissistic techbros and presidents have already lined up to create clones of themselves not "watered down" by needing another set of genes?
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They wouldn't be clones, more like extra-close siblings. All sperm have a different mix of chromosomes, so any paring wouldn't match the donor's exact mix of genes.
You have 23 pairs of chromosomes. When sperm are created, a parent cell splits its dna in two to produce two sperm cells. The chromosomes from each pair are assigned randomly to the sperm cells.
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I understand some of the article, but you need a few college classes in
genetics to fully understand the whole thing in my opinion.
genetics to fully understand the whole thing in my opinion.
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Ok, wasn't this what happened to Bortus and Klyden on The Orville? Theirs was in an egg (makes sense if you don't have a uterus).
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Gay, transgenic, mixed-race, foreign mice.
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This is actually really neat!
I hope though they can work on the 'growth' mechanism though.
The reality is we need the option to tank-grow offspring/clones sooner rather than later.
Creating real life Axloti Tanks would be ethically wrong in every sense.
We need a synthetic solution.
I hope though they can work on the 'growth' mechanism though.
The reality is we need the option to tank-grow offspring/clones sooner rather than later.
Creating real life Axloti Tanks would be ethically wrong in every sense.
We need a synthetic solution.
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Yeah...but I was promised fully synthetic life forms, robots indistinguishable from humans, flying cars (actually almost here), and fusion power too cheap to meter. Timeline representative? I demand to speak to the manager!
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Anyone who thinks this technology is ready to be applied to people, who have complex behavior, live 70-80 years, and procreate , is a gibbering idiot. Maybe in a decade or two. 40+ years ago I worked on antipsychotic drugs which were tested in mice, and we did not know which furry test tubes thought they were Napoleon before treatment-or after treatment. My suspicion was that we just made the mice feel so sick that they did not give a rat’s ass.
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This is actually one of those things that's just fascinating the more you think about it, because it really is more than needing a phospholipid bilayer and some mitochondria. As much as the article and the research focuses on the nuclear DNA, there's so much more to a cell, and especially to an unfertilized ovum that deserves at least as much attention.
Now that I think about it, the article didn't mention the possibility of any sort of mismatches between mitochondrial and nuclear DNA, especially since they're using nuclear DNA from distantly related subspecies...
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Someone might wish to explain the many hereditary diseases that the royal houses of Europe discovered/created trying to do something similar over the centuries. Eventually the murder of poor Franz Ferdinand triggered all that hereditary insanity and we had a bloodbath, but it did take care of the "too many inbred royals" problem rather permanently.
I'm not saying WWI was a good thing, just that it seems like the inevitable endpoint for inbred aristocrats.
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I think we should go one step further. I mean past inherited political power, not the assasination of "aristocrats". Just assasinate their inherited power. No one alive pays taxes. All tax bills come due when you die.
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Not gay transgenic mice. This is a break through for alpha males! Strong dominant opinionated men now no longer need to worry about being left out of the gene pool. All they need to do now is find a woman that wants to deliver their beautiful baby.
...
Oh, never mind.
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Very very long way to go I imagine. The efficiency would have to be really damn high to ethically allow this sort of thing with humans. Seems from this article that there is an awful lot we yet don't understand and I imagine that even 1% of such children being disabled or dying at birth would be a no-go for this technology. Currently it's 247/250.
But yes, one day, this could be exciting for same sex parents.
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I guess if you did something similar with two egg cells, you would only be able to produce female offspring right?
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Any idea how many such modifications are needed (just the 7 sites mentioned controlling multiple nearby genes?)? Given the success rate is it just a problem of consistently and correctly reprogramming just the 7?
And did the scientists identify any other key regions where this wouldn't be lethal but still cause issues, small or big?
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