And it's still dicey to get even pairs of matched sets to play nice together. When I built my current AM5 build, I went with 32GB of RAM -- two matched 16GB sticks. But very quickly discovered I needed 64GB minimum (I'm pretty much sitting with 20-30GB of RAM in use all the time, etc.)
So I bought another identical set (my board is dual-channel, but has 4x sockets...two dual-channel setups) and couldn't get the same 6000 level overclock with 4x as I could with the previous 2x. Using the autotune feature, my current system is currently staying happy at around 5800 in regard to memory bandwidth.