When the electrician comes in to replace the timer on the lights for the your floor, it would be best if you reminded him to not accidentally put the IT room circuits on said timer as well.
When you ask your employees for a list of parts and say you're going to order them it's fun to F with them by asking if they have ordered the parts yet.
Of course, things like Application Isolation or ThinApp or App-V (SoftGrid) can really reduce the chances of applications stomping on each other, so you can really de-silo-ize if you're using those.
If you're running into these issues regularly then the team really should look at virtualizing the apps. I'm sure there would be reasons to build silos of servers instead but I can't imagine that whatever those reasons are they add up to 50k/hr downtime.
