Half the fun is creating the perfect storage system! I don't have Toxicity, though.
One of my peeves is when I think I have everything figured out as far as how I'm sorting things, and then I have to stick something else in there. I can either create a bunch of temporary storage and try to move things around, or I can stick it on the end and be reminded of it every time I go get it.
Since I automated my crushers, I don't really need to have three T2 lockers full of dolomite, bauxite, and uraninite outside anymore. But I also don't have a good place I can fit them inside. I'm thinking of just moving them to the basement. Other than creating the rock crusher, I don't think they are used to make anything. They are mostly there if there is a breakdown and I need to manually run stuff through the crushers.
I've improved my automation and mostly gotten it out of the basement. The issue with having it in the basement is it pulls form my stockpiles, which then have to be replenished. What I'm doing now is setting up mini-factories where the overflow is sent to low priority lockers, and then autocrafted from there, and drones take it back to my storage. I keep the factories separated so they can't steal from each other's stockpiles, and I group similar things together. For example, I have one mini-factory just making rods out of the stuff that can make rods. And since it is doing it with all the overflow, it doesn't take away from my storage. If I had thrown that in the basement, it would have taken ALL of my iridium and turned it into rods and I wouldn't have had any iridium until the rods were full. This lets me work around that.
Also, since I'm going to have a bunch of factories using some of the rarer materials, I doubled the extractors getting uraninite, and then ran into another trouble. It was going to take a while before the second crusher would start receiving the materials because they were all going into the first crusher. And since the crushers work a LITTLE faster than the extractors, it just wasn't efficient to wait. So instead I dropped a production fuse on the extractors so they would work a little FASTER than the crushers. This isn't Satisfactory, I'm not being judged by my efficiency (and I don't have a splitter). That and dropping some stockpile meant I doubled my production.
And finally, I found a LITTLE bonus. I've automated my mutagens, but T4 takes two T1 mutagens to make, which means it is made twice as slow. And I didn't feel like doubling my mutagen production as that would be annoying and would become redundant once I caught up. So I wanted a ready supply of both common larva and mutagen, and I realized you can throw the butterfly larva in the recycler! I have a few larva farms around the map (where it tells you that certain larva spawn after the second map info rocket, though I may have messed one up, not sure if it is above or below ground). Anyway, they have gotten me 10 of each of the larva and rather than shredding the extras, I made a small box for the overflow to drop into and then I throw them through the recycler and I get a ton of common larva and t1 mutagen! That is helping kick start the production lines.
At this point there is little reason to do the wrecks. I could probably run them for more fuses and TT. Though I've found an area that spawns butterfly larva I can sell for 4500 tt, so technically I could have as much as I want without doing wrecks.
I'm running with 30 drones now. Once I started setting up my factories they began getting a little behind so I gave them some friends to help.