“But Americans can rest easy because Martin Shkreli is a pharma bro no more… The rich and powerful don’t get to play by their own set of rules, so it seems that cash doesn’t rule everything around Mr. Shkreli," Attorney General James continued.
Why is anyone talking about pricing of a drug that was discoverd in 50's and should be out of patent since about 50 years?
Why aren't there multiple generics available for about 2c/pill in every pharmacy and why don't medicare, medicaid and insurances automatically enforce using the practically free generics that obviously should be available everywhere?
Seems like the is a relatively simple supply side fix available here?
edit: oh, wiki tells me that a generic was approved 2020. Why on earth didn't one appear like 40-50 years ago?
I think the market for a drug like this is much smaller than say paracetamol. Therefore, much less competition, which is perhaps why it became the target of this dastardly scheme.
Remember that even generics manufacturers need to turn a profit in order to stay in business.
I applaud this outcome. But this happens all the time from other more traditional pharma companies. Why do they get a free pass?
(Honest question - I am genuinely curious)
I know that drugs like these get patents so that the inventors can enjoy some profit-making before others can compete with them, but in practice, should we even encourage profit-making in the healthcare industry?
We need some better way to incentivize researchers to find cures and treatments than just a pure market model. As-is, there are people who profit off scenarios where patients go into debt for life because of the developed treatments' exorbitant costs, and in terms of where we are now, it's not even the doctors and scientists who end up with the majority of that money, it's corporate VIPs and investors.
An alternative would be to have a system where the payer can actually negotiate a realistic price for treatment, even in the event there is no competition for it. A system where the seller has no choice but to sell to the payer, because there aren't any other payers. One might call that a single-payer system...
The FDA does have a system in place for that. Which is precisely what Shkreili's scam took advantage of (along with others, he was certainly not the only jerk in this space).
Basically, if you are willing to do the paperwork to keep the drug's manufacturing up to modern standards, you get an exclusive license to produce the drug. Sort of a mini patent. It has worked for some drugs and some companies, but left with some loopholes to drive trucks filled with money through.
No good deed goes unpunished...
Since the claim about the US subsidising the rest of the world is often raised, it does need some qualification. Whilst often used by US lobbyists to justify drug prices, that is far from the full story. For a start, a lot of costs are in marketing and advertising that are not incurred elsewhere, and expenditures besides R&D. For another, countries like the UK do consider that they pay a fair share, not least as a policy because they have their own pharmaceutical industry. The UK also encourages research in areas like antibiotics which are not considered profitable, and committed billions to Covid vaccines whilst Trump was still publicly denying that the disease was a problem for the US. There are certainly plenty of free riders internationally, many of whom cannot of course afford to do otherwise.Good. One greedy f*ck down. Now how about universal healthcare?
Universal healthcare alone won't solve the problem except for covering everyone. The much larger problem is that costs are too high, as compared to any and every country on earth. The fact that the US pays many times the cost (think Shkreli multiples) for the same drug that all other countries, including first world countries, is a place to start.
Legalize and encourage going to other countries for expensive procedures. The fact that you can travel, stay and get a procedure done and still save insurance companies money tells me something is f'd. Also fix prices of drugs to the average of what the rest of the first world countries are paying. The US is basically subsidizing the entire world and it needs to stop. If Pharma can't make a profit by signing on to this, then don't make the drug. Simple.
I agree with you 100%. Right up to the last bit. While I agree the US is subsidizing the entire world for health research, the alternative is ceding that lead to China, which in itself isn't a problem, until you consider that the Chinese government might decline to share their advances with the rest of the world. Otherwise, yes, big pharma needs regulation to bring the industry in line with it's actual purpose.
Edit: type, then click
Why is anyone talking about pricing of a drug that was discoverd in 50's and should be out of patent since about 50 years?
Why aren't there multiple generics available for about 2c/pill in every pharmacy and why don't medicare, medicaid and insurances automatically enforce using the practically free generics that obviously should be available everywhere?
Seems like the is a relatively simple supply side fix available here?
edit: oh, wiki tells me that a generic was approved 2020. Why on earth didn't one appear like 40-50 years ago?
For all his faults, and there are many, he and his partner were rather clever.
From TFA:
"Shkreli and Mulleady allegedly set up a complex scheme that kept the drug out of the hands of competitors, restricted suppliers from selling critical drug ingredients to competitors, and blocked the release of sales data that would reveal the market size to competitors."
They actually had to do a lot of work to get this fraud going.
Derek Lowe has followed him for some time. This post can get you started and then you can wander down the rabbit hole if you're interested.
TL;DR - this gets you pretty far:
By various means, old generic compounds have ended up as protected species, and several companies have made it their business to take advantage of these situations to the maximum extent possible. The FDA grants market exclusivity to companies that are willing to take "grandfathered" compounds into compliance with their current regulatory framework, and that's led to some ridiculous situations with drugs like colchicine and progesterone. (Perhaps the worst example is a company that's using this technique to get ahold of a drug that's currently being provided at no charge whatsoever). There are also loopholes that companies are trying to exploit when competitors try to prove generic equivalence: whatever it takes to keep competition away and get unlimited pricing power.
Most other countries do not think it necessary to jail some for 20 years and reward the rest, though. Much of America's problem is that greed is not seen as immoral, but admirable.Why is anyone talking about pricing of a drug that was discoverd in 50's and should be out of patent since about 50 years?
Why aren't there multiple generics available for about 2c/pill in every pharmacy and why don't medicare, medicaid and insurances automatically enforce using the practically free generics that obviously should be available everywhere?
Seems like the is a relatively simple supply side fix available here?
edit: oh, wiki tells me that a generic was approved 2020. Why on earth didn't one appear like 40-50 years ago?
For all his faults, and there are many, he and his partner were rather clever.
From TFA:
"Shkreli and Mulleady allegedly set up a complex scheme that kept the drug out of the hands of competitors, restricted suppliers from selling critical drug ingredients to competitors, and blocked the release of sales data that would reveal the market size to competitors."
They actually had to do a lot of work to get this fraud going.
Derek Lowe has followed him for some time. This post can get you started and then you can wander down the rabbit hole if you're interested.
TL;DR - this gets you pretty far:
By various means, old generic compounds have ended up as protected species, and several companies have made it their business to take advantage of these situations to the maximum extent possible. The FDA grants market exclusivity to companies that are willing to take "grandfathered" compounds into compliance with their current regulatory framework, and that's led to some ridiculous situations with drugs like colchicine and progesterone. (Perhaps the worst example is a company that's using this technique to get ahold of a drug that's currently being provided at no charge whatsoever). There are also loopholes that companies are trying to exploit when competitors try to prove generic equivalence: whatever it takes to keep competition away and get unlimited pricing power.
It's almost nice to see a criminal making some effort. It stings more when criminals are so bloody stupid but only get slaps on the wrist for massive financial crimes, that's when you start asking why you bother being a good person. You like to think you'd be an excellent criminal if it weren't for the morals, know what I mean?
I know that drugs like these get patents so that the inventors can enjoy some profit-making before others can compete with them, but in practice, should we even encourage profit-making in the healthcare industry?
We need some better way to incentivize researchers to find cures and treatments than just a pure market model. As-is, there are people who profit off scenarios where patients go into debt for life because of the developed treatments' exorbitant costs, and in terms of where we are now, it's not even the doctors and scientists who end up with the majority of that money, it's corporate VIPs and investors.
An alternative would be to have a system where the payer can actually negotiate a realistic price for treatment, even in the event there is no competition for it. A system where the seller has no choice but to sell to the payer, because there aren't any other payers. One might call that a single-payer system...
The FDA does have a system in place for that. Which is precisely what Shkreili's scam took advantage of (along with others, he was certainly not the only jerk in this space).
Basically, if you are willing to do the paperwork to keep the drug's manufacturing up to modern standards, you get an exclusive license to produce the drug. Sort of a mini patent. It has worked for some drugs and some companies, but left with some loopholes to drive trucks filled with money through.
No good deed goes unpunished...
"have a system where the payer can actually negotiate a realistic price for treatment"
Like a single-payer system? Like Canada and every other industrialized world?
Where Medicare is not only allowed but encouraged to negotiate drug prices (Which was in the 'Build Back Better Bill' Thanks for nothing Manchin)
I know that drugs like these get patents so that the inventors can enjoy some profit-making before others can compete with them, but in practice, should we even encourage profit-making in the healthcare industry?
We need some better way to incentivize researchers to find cures and treatments than just a pure market model. As-is, there are people who profit off scenarios where patients go into debt for life because of the developed treatments' exorbitant costs, and in terms of where we are now, it's not even the doctors and scientists who end up with the majority of that money, it's corporate VIPs and investors.
An alternative would be to have a system where the payer can actually negotiate a realistic price for treatment, even in the event there is no competition for it. A system where the seller has no choice but to sell to the payer, because there aren't any other payers. One might call that a single-payer system...
Why is anyone talking about pricing of a drug that was discoverd in 50's and should be out of patent since about 50 years?
Why aren't there multiple generics available for about 2c/pill in every pharmacy and why don't medicare, medicaid and insurances automatically enforce using the practically free generics that obviously should be available everywhere?
Seems like the is a relatively simple supply side fix available here?
edit: oh, wiki tells me that a generic was approved 2020. Why on earth didn't one appear like 40-50 years ago?
Judge Cote further elaborated on her ruling by issuing the following statement:
"Shimmy shimmy ya shimmy yam shimmy yay"
![]()
Since the claim about the US subsidising the rest of the world is often raised, it does need some qualification. Whilst often used by US lobbyists to justify drug prices, that is far from the full story. For a start, a lot of costs are in marketing and advertising that are not incurred elsewhere, and expenditures besides R&D. For another, countries like the UK do consider that they pay a fair share, not least as a policy because they have their own pharmaceutical industry. The UK also encourages research in areas like antibiotics which are not considered profitable, and committed billions to Covid vaccines whilst Trump was still publicly denying that the disease was a problem for the US. There are certainly plenty of free riders internationally, many of whom cannot of course afford to do otherwise.Good. One greedy f*ck down. Now how about universal healthcare?
Universal healthcare alone won't solve the problem except for covering everyone. The much larger problem is that costs are too high, as compared to any and every country on earth. The fact that the US pays many times the cost (think Shkreli multiples) for the same drug that all other countries, including first world countries, is a place to start.
Legalize and encourage going to other countries for expensive procedures. The fact that you can travel, stay and get a procedure done and still save insurance companies money tells me something is f'd. Also fix prices of drugs to the average of what the rest of the first world countries are paying. The US is basically subsidizing the entire world and it needs to stop. If Pharma can't make a profit by signing on to this, then don't make the drug. Simple.
I agree with you 100%. Right up to the last bit. While I agree the US is subsidizing the entire world for health research, the alternative is ceding that lead to China, which in itself isn't a problem, until you consider that the Chinese government might decline to share their advances with the rest of the world. Otherwise, yes, big pharma needs regulation to bring the industry in line with it's actual purpose.
Edit: type, then click
The reality is that whilst the US remains the most profitable market, companies will commit their biggest efforts to satisfy it. That is frequently accused of distorting research because the priority is often to match the competition, not find novel treatments.
And along the way, the UK still manages to obtain generics, like insulin, a lot cheaper than the US whilst paying world market prices.
What national figures for drug R&D spending do not capture, of course, is the fact that companies try to recover those costs from worldwide sales. So UK residents pay indirectly for R&D which takes place in the US on the drugs they use. [How they do so is complicated, because the UK does not regulate prices directly, but does negotiate a price which the NHS will reimburse dispensers. Only hospital drugs are bought directly by the NHS.]Since the claim about the US subsidising the rest of the world is often raised, it does need some qualification. Whilst often used by US lobbyists to justify drug prices, that is far from the full story. For a start, a lot of costs are in marketing and advertising that are not incurred elsewhere, and expenditures besides R&D. For another, countries like the UK do consider that they pay a fair share, not least as a policy because they have their own pharmaceutical industry. The UK also encourages research in areas like antibiotics which are not considered profitable, and committed billions to Covid vaccines whilst Trump was still publicly denying that the disease was a problem for the US. There are certainly plenty of free riders internationally, many of whom cannot of course afford to do otherwise.Good. One greedy f*ck down. Now how about universal healthcare?
Universal healthcare alone won't solve the problem except for covering everyone. The much larger problem is that costs are too high, as compared to any and every country on earth. The fact that the US pays many times the cost (think Shkreli multiples) for the same drug that all other countries, including first world countries, is a place to start.
Legalize and encourage going to other countries for expensive procedures. The fact that you can travel, stay and get a procedure done and still save insurance companies money tells me something is f'd. Also fix prices of drugs to the average of what the rest of the first world countries are paying. The US is basically subsidizing the entire world and it needs to stop. If Pharma can't make a profit by signing on to this, then don't make the drug. Simple.
I agree with you 100%. Right up to the last bit. While I agree the US is subsidizing the entire world for health research, the alternative is ceding that lead to China, which in itself isn't a problem, until you consider that the Chinese government might decline to share their advances with the rest of the world. Otherwise, yes, big pharma needs regulation to bring the industry in line with it's actual purpose.
Edit: type, then click
The reality is that whilst the US remains the most profitable market, companies will commit their biggest efforts to satisfy it. That is frequently accused of distorting research because the priority is often to match the competition, not find novel treatments.
And along the way, the UK still manages to obtain generics, like insulin, a lot cheaper than the US whilst paying world market prices.
Yup, total US spending by pharmaceutical companies in 2020 was approximately $91 billion, up a little from last year.
Direct to consumer advertising was $6.58 billion. Now, that doesn't seem TOO bad. Though, again, why the FUCK are companies advertising something that MUST be prescribed by a doctor, who should know best what to prescribe?
But that doesn't capture the roughly $25 billion per year in NON-direct to consumer marketing they do. About $20 billion of that is spend on direct to PRESCRIBER marketing to influence doctors (IE bribes).
So about 1/3rd of the R&D budget in the US.
If you want to get really steamed about it, the US pharmaceutical MARKETING budget for one year is sufficient to fully fund UK R&D pharmaceutical efforts for about 5 years (~4.7 billion GBP in 2019)
How is there a Wu-Tang album with only one existing copy?Oh no, the poor fella had to give up his $2 million Wu-Tang album? That's just so... hilarious.
He'll never be a CEO of a Pharma company. There are plenty of other industries out there where he can still be a CEO.good he'll never be a ceo again.
I'd call this a win but their claim that the rich can't play by their own rules is factually false. It has been proven beyond a doubt that they totally do play by their own rules and that they do so with impunity. He didn't get in this mess because anything of what he did was illegal the whole thing started because he BRAGGED about it then went and flaunted his privilege all across the senate faces in a hearing. Had he not basically tea-bagged senators in such a shameless way no scrutiny would have happened. Its entirely possible that his actual crime of securities fraud would have gone completely unnoticed. The rich do get away with anything.
Just ask Trump. In his own words "He grabs them by the pussy" exclusively because "When you are rich, they let you do anything" He also got away with sneaking into the dressing rooms of minors and 18 year old on the pageants he used to own.
This is why that AG's words ring hollow, we know and seen too much proof already that the rich are the ruling class in the US and thus get away with things the average citizen will never be able to.
They aren't afraid because of what he did (what he did was small potatoes in comparison to his pharma peers)
They are afraid because he did it all so publicly, blatantly, and honestly.
Anyone who thinks that this is justice must surely be joking. The only practice on display is homeostatic maintenance of the underlying exploitation engine. Systems of enslavement seek to produce slaves, not the enslaved. Consequently, anything that could undo said conversion must be punished, which sufficiently harsh exploitation does. Which is why we don't practice chattel slavery anymore, it's just not very effective. It being evil had nothing to do with it. There is no such thing as justice in the US
Cheese ball references don’t cover for the fact Shkreli was a slam dunk case. Its nice to see justice but the scale of the crime is beans compared to the big boys. Shkreli got caught for flaunting, not the crime. The titans are happy to see a smug little shit catch some charges for being brash. They can all pretend to be aghast, the prosecutors look like heroes, the public gets its schadenfreude, and nothing fundamentally changes.
If America’s chickenshit (Jim Comey’s words, not mine) prosecutors recovered their spines, and remembered they could prosecute corporations & cases when they aren’t 100% sure they could win, then they can claim to be on the shaolin path.
They aren't afraid because of what he did (what he did was small potatoes in comparison to his pharma peers)
They are afraid because he did it all so publicly, blatantly, and honestly.
I think "aghast" is a better word than afraid.
How is there a Wu-Tang album with only one existing copy?Oh no, the poor fella had to give up his $2 million Wu-Tang album? That's just so... hilarious.
Good. One greedy f*ck down. Now how about universal healthcare?
Universal healthcare alone won't solve the problem except for covering everyone. The much larger problem is that costs are too high, as compared to any and every country on earth. The fact that the US pays many times the cost (think Shkreli multiples) for the same drug that all other countries, including first world countries, is a place to start.
Legalize and encourage going to other countries for expensive procedures. The fact that you can travel, stay and get a procedure done and still save insurance companies money tells me something is f'd. Also fix prices of drugs to the average of what the rest of the first world countries are paying. The US is basically subsidizing the entire world and it needs to stop. If Pharma can't make a profit by signing on to this, then don't make the drug. Simple.
If they break the law within ten years, in addition to getting prosecuted for the new crime, they’ll get hit for charges relating to this old crime as well.“ The settlement also required the companies to make Daraprim available to competitors at cost and barred them from entering into any similar scheme for 10 years.”
Wait. So they can jack up the price again in 10 years? That’s not solving the problem, that’s just kicking the can down the road.![]()