There's definitely news/notoriety/financial pressure on Nature & Science editors. I mean, you don't want to be known as the editor that rejected a paper that turned the tables on current science and broke open a whole new field of study.
They have to constantly check their distrust of conflicting data, simply because real breakthroughs have happened before. And data is often messy (it's rarely a perfect, beautiful graph)
So it's a tough balance. And they know science will win out in the end, as other scientists try to repeat that results.
But the fewer of these disasters on your publications resume—or should I say CV—the better.