It's unclear how much savings the deal provides or how many people will benefit.
See full article...
See full article...
Questions swirl after Trump’s GLP-1 pricing deal announcement
- Thread starter JournalBot
- Start date
By the time the fact check is completed, 5 more lies, including 2 even more outrageous ones, have left his beautiful lips.
Upvote
6
(6
/
0)
Overstating public gains is pretty much policy with this administration. If you start off by not believing them you save yourself a lot of time.
Upvote
0
(0
/
0)
Upvote
17
(18
/
-1)
Everyone should have access to GLP-1 drugs they’re not a shortcut, they’re a tool to help people take control of their health. Obesity is a national epidemic, and these meds address real biological challenges, not just willpower.
I’ve been into fitness for 25 years 6 days a week and I fully support anything that helps people curb cravings, build habits, and live healthier, longer lives. Access shouldn’t depend on income or insurance, it should be part of the solution.
I’ve been into fitness for 25 years 6 days a week and I fully support anything that helps people curb cravings, build habits, and live healthier, longer lives. Access shouldn’t depend on income or insurance, it should be part of the solution.
Upvote
12
(13
/
-1)
I searched a bit, and it seems berberine is good for blood sugar. But most of the myriad other uses it claims (none of the reputable medical sites I checked listed "weight control"), get ratings like "may possibly work". It doesn't sound like it has been established as useful. And (this may be a US thing, since "supplements" here have almost no regulation) none of the OTC brands I looked at showed third party testing for what was actually in the caps (one touted "THIRD PARTY LABORATORY TESTED" but didn't name the lab, so it might be "Breaking Bad Lab", unless some clever scammer has formed a company named "Third Party Laboratory" to operate from his garage).
Upvote
7
(7
/
0)
In any case, since the oligarchs who own the media mostly are backing Trump, even if the journalist asks difficult questions they will probably get spiked by their editor.
Upvote
3
(3
/
0)
The website is https://trumprx.gov/, go check it out for a good laugh. Currently it says it's "Coming Soon" in Jan 2026.
Upvote
3
(3
/
0)
The only dick i suck is mine. Not that there’s anything wrong with that.
Upvote
-18
(0
/
-18)
Trump isn't Republican. Trump is Trump and he only does shit that benefits him.
Upvote
-9
(1
/
-10)
I think it's going to be fun seeing what happens in 2026. As you might recall, the GLP-1 patents expired in Canada, and 2026 is when the generic drug makers are planning on starting to sell generic GLP-1 drugs. In Canada, this will drop the price rather significantly. But at the same time, those drugs will be illegal to be sold in the US as they're still patented. And none of the drugs could be made in the US - they have to be made in Canada.
Be interesting to see if they set up shops just across the border to fill GLP-1 prescriptions - they cannot be sold in the US, but Americans can buy "personal use" amounts in Canada legally (usually 3 months worth). Even if they sell it for more than what Canadians will pay, it'll still be cheaper than in the US and very profitable.
Or maybe, given the US border patrol's overzealousness, it'll be injected in Canada and then Americans will cross back with nothing. Just a little day trip into Canada to go for a walk. (Might as well - the border waits have basically disappeared making it easy to cross)
Be interesting to see if they set up shops just across the border to fill GLP-1 prescriptions - they cannot be sold in the US, but Americans can buy "personal use" amounts in Canada legally (usually 3 months worth). Even if they sell it for more than what Canadians will pay, it'll still be cheaper than in the US and very profitable.
Or maybe, given the US border patrol's overzealousness, it'll be injected in Canada and then Americans will cross back with nothing. Just a little day trip into Canada to go for a walk. (Might as well - the border waits have basically disappeared making it easy to cross)
Upvote
3
(3
/
0)
But The Orange One promised drug prices would be reduced by at least 1,000%:
https://edition.cnn.com/2025/09/23/politics/fact-check-drug-prices-trump
I'm very disappointed that big pharma won't be paying patients to take their drugs.
https://edition.cnn.com/2025/09/23/politics/fact-check-drug-prices-trump
I'm very disappointed that big pharma won't be paying patients to take their drugs.
Upvote
9
(9
/
0)
100% agreed! Well 99%: the drugs are GLP-1 agonists, not antagonists.
Upvote
1
(1
/
0)
Good news, injuries and other ailments that make excercise difficult or impossible don’t exist anymore.
Ignorance seems to be on the rise though.
Upvote
10
(10
/
0)
I believe Dr Watson's more famous friend also had a solution, specifically, a 7% solution, that some have touted for weight loss*.
(foghorn leghorn voice): Ah say...ah say thas a JOKE son...a JOKE.
*Cocaine should only be administered by trained medical personnel in the normal practice of medicine on the authority of a licensed practitioner with a suitable controlled substance cerification
The 7% Solution is a great Sherlock Holmes romp
Upvote
0
(2
/
-2)
When I heard about the trumprx website, my first instinct was to try to register the domain. Sadly, this effort is better planned than most of the current administration’s actions.
Upvote
0
(0
/
0)
Injuries and other ailments that make exercise difficult or impossible still exist. And the good news is that there are new and extremely efficacious medications to help people who suffer from those injuries and ailments. The bad news if that for many unafflicted others whose lifestyles and behaviors are within their control to change, these medications will be used in lieu of adjusting their behaviors, permitting them to avoid root causes and encouraging the continuation of causal unhealthy behavior patterns and thus resulting in never achieving a healthier holistic solution.
Of course, the manufacturers of these drugs strongly discourage the overprescribing of these medications, even at the expense of profits: they only have the good health and well-being of people in mind and would never create a drug that might be improperly used. Pharmaceutical companies have consistently demonstrated exemplar ethics, and I have no doubt that Novo Nordisk and Eli Lilly will responsibly advertise only to those with injuries and other ailments that make exercise difficult or impossible, and it is certain that drug reps will discourage the use of these medications by those whose lives could be more foundationally and holistically improved by changing fundamental lifestyle behaviors.
Of course, all this assumes that there is such a thing as people who have agency and are capable of making changes for the betterment of their lives. I think that it's becoming increasingly established as a scientific fact that individual responsibility is a myth; and if that is eventually proved to be an indubitable truth, then we can be grateful for companies like Nordisk and Eli Lilly who can selflessly help us through our helplessness.
Upvote
-8
(2
/
-10)
I've lost over 25 kg, one third of my healthy weight, on Rybelsus alone. Eating restrictions are fine, the whole point of this drug is to limit the appetite. I just don't eat breakfast and drink my first coffee at desk. It is easily available in pharmacies, unlike the injectables, and is relatively cheap at 388 Polish złoty or about €90 or $105 per 30 pills. Now that I'm down to healthy BMI, I take the 14 mg pills cut in half, because it costs the same for 14, 7 and 3 mg. I take my vitamin D with it too, nothing on the leaflet says it cannot be taken with other drugs, just no food nor drink. I can easily stock up half-yearly supply. Yes, dividing the pill is against manufacturers, very poorly motivated recommendation... Neither I, nor my doctor care. It is as if the expected profit for yearly therapy was set to €1000, which is still too much for something to be taken whole life. But at €500 it might actually mostly balance out the unboght food.
TL;DR: Rybelsus in my experience is perfectly fine for weight loss.
Last edited:
Upvote
1
(2
/
-1)
You're getting down-voted as you should, but just in case you actually want to learn rather than be self-righteous, do some research about GLP-1 and GLP-2. Some people have genetic factors and conditions that cause impairment to the functions of the hormones, so it's not simply a case of leading unhealthy lifestyles.
Unsurprisingly, when they get medication that improves the regulation of, or introduces these hormones, they find themselves eating less because they're not feeling hungry all the time (due to no fault of theirs) and consequently, they lose weight and start having better health markers.
You're not alone, even lots of doctors think it's cheating to take these meds, even though they should know better due to their understanding of human anatomy.
Upvote
8
(8
/
0)
What happened to lowering costs on insulin, for people who actually need it to stay alive?
Upvote
1
(1
/
0)
Didn't COVID teach you about a Trump administration's feeling about keeping people alive?
Upvote
5
(5
/
0)
GLP-1 went through the full FDA approval process with extensive clinical trials evaluating both safety and effectiveness. You really can't compare it with a supplement that has virtually no data or testing behind it.
GLP-1 is safe and effective, with well-defined side effects. Your supplement might work, but there is no evidence of that and side effects are unknown.
Upvote
14
(14
/
0)
Pre-RFKJr FDA just to be thorough about it. Post carries less weight unfortunately.
Upvote
2
(2
/
0)
As a doctor if we see someone in a catabolic state (i.e. essentially digesting themselves) we take action, you absolutely should be taking these under a doctor's care. It's not that common to see it, but yes some people do become catabolic as they essentially stop eating rather than just reduce caloric intake. There is a minimum protein intake (and most people don't really understand what protein means in diet) and if you aren't taking it (along with some carbs) after using up your glycogen stores, you will first enter starvation ketosis (before someone foams, that is not the same as diabetic ketoacidosis, we all go into starvation ketosis virtually every night it's fine and is part of our normal metabolism) but if you don't get some carbs and protein before the body can't sustain the ketone output you start into catabolism where we use our own protein (i.e. muscle) to make the ketones. This is the premise of the ketogenic diet, it's not zero carbs, it is a carefully calculated quantity to prevent catabolism but keep turning fat into ketones.
Upvote
10
(10
/
0)
I am being perfectly rational. The difference between a supplement and a medication are often just evidence, dosing standards, and manufacturing standards. If they had the evidence to make medical claims, they'd be marketed as drugs.
Berberine at most has enough evidence to be worth further study. Most of its "evidence" is both mixed and in studies that likely are biased due to flaws in the methodology.
The thing is we have extremely strong evidence of the effects of GLP-1 drugs, which are far more effective for weight loss than anything else we've ever had. We have strong evidence of improvements to heart heath. We have strong evidence of significant improvements on blood glucose control for type 2 diabetics.
I want myself and my loved ones to take the most effective and safest treatments possible. If you feel there is too much unknown about GLP-1 medications, there are other drugs that are as or more effective than berberine (in its most flattering studies) that have been around for a long time like appetite suppressants and drugs like Metformin.
But if your loved one is struggling to lose significant weight, nothing comes anywhere close to what GLP-1 medications can do.
And the reaction is in comparison to the OP saying that berberine is just as effective as GLP-1 medications.
Upvote
7
(7
/
0)
Would it surprise you if MAHA doesn't believe in insulin, and that the right diet and exercise can cure diabeties?
Upvote
0
(0
/
0)
The question is that why we need these drugs. From which system, do we have so many "patients" need these? Why there are much less demands in other markets?
Upvote
-13
(0
/
-13)
Easy. Republicans have no actual stances except "what the party says". Not so much out of malice, IMO, but from ignorance of what things are when separated from certain buzz words, and allowing themselves to be spoonfed opinions by media like FOX news.
If you talk to a Republican, at least in my experience, they support plenty of Liberal policies...until they realize that's what they are.
Upvote
1
(2
/
-1)
Because in the US, highly processed foods are cheap, health foods are expensive, and people's wages are losing to inflation.
Upvote
3
(5
/
-2)
I don't entirely believe you. I also have BCBS. I am on Wegovy. Zepbound (Wegovy equilvant from Lilly) is not even covered by BCBS. This means I wouldn't even be able to get it for the $550+ a month that I can get Wegovy for, now if I didn't go through insurance, I could get Zepbound for ~$550.
The BCBS website says it's $350 for Mounjaro. Zepbound is not even covered the 2026 plan.
Upvote
0
(0
/
0)
You can't seriously still be saying that. The Republican Party has chosen for Trump to define what modern Republicans are. Most Republicans support what he's doing. He has won two elections now, and is talking about a third with support from his party. In what way is he not Republican at this point? Are you still holding onto some delusion that Republicans are somehow more moderate than he is, and just powerless to fight back against him? There are conservatives that do not like him, but at this point that pits them against the Republican party.
Upvote
7
(8
/
-1)
"I don't think you can accept that GLP-1 will be great because it's prescription and berberine must be worthless because it's a supplement."
And yet, you assume GLP-1 is worse than we think, and Berberine is better because one comes from the medical establishment and one doesn't. Do you not see the hypocrisy?
Also, how often has the 'wellness' industry been the victor against actual medicine, by any standards except their own? If a medicine works well, why sell it as an unregulated supplement that doesn't have to prove its claims, instead of sending it through the official channels to demonstrate those claims? Because I can only think of one reason - it doesn't perform as well as claimed.
Upvote
5
(6
/
-1)
I fear this will end up like "affordable insulin", when my copay of $34 for a 90 day supply of Humalog almost tripled to $108 for a 90 day supply. On top of that drug pricing in the US is about as transparent as the water in NY harbor.
Upvote
1
(1
/
0)
Why change your diet or exercise when all you have to do is take a pill? /s
This is the attitude of most people. My mom has this exact attitude about her diabetes - she can eat things she isn't supposed to eat, because it's being controlled by medication.
As for protein, I would guess that most people
a) don't know what protein is, other than "meat"
b) don't know how much they are getting
c) don't know how much they should be getting
The US RDA for protein is 0.8g per kg of bodyweight. (or 0.36g/lb) But that is minimum. The current thinking is 1.5g/kg or even higher depending on your goals, activities, age, etc. Not to mention that if you are obese, it shouldn't be compared to your current weight, but of your target weight. (it should really be based on muscle mass, not on body weight but that's too difficult to measure)
A pretty recent podcast with Rhonda Patrick on this exact topic: https://peterattiamd.com/rhondapatrick3/
Last edited:
Upvote
-1
(0
/
-1)
My mental model for Type 2 diabetes: Your body creates insulin but it works very badly. So your blood sugar goes up and up and eventually that hurts you.
Metformin makes the insulin work better. If you take Metformin together with too much sugar your blood sugar goes up to a limit (because your body makes lots of insulin which works a bit better because of Metformin), but that stable state is still too high and unhealthy in the long term.
Eat the recommended amount of sugar (60g as printed on packages plus 30g that you don’t know about) and the blood sugar is lower, still not good, but a lot less damage. Drop your sugar intake below what a healthy person would be allowed and your blood sugar level becomes more or less normal.
So if you take much more sugar than a healthy person should, Metformin keeps the damage at “very bad for you” level instead of “kills you quickly” level. You still reduce your life span considerably.
Upvote
0
(1
/
-1)
Anton Longshot
Ars Praetorian
Interesting article pic.
As I mostly avoid "news" it's been a while since I saw a recent Trump pic.
He seems to have deteriorated quite a bit.
The people standing near him made me laugh out loud. Hilarious.
Just look at their postures and their faces and what/who they are looking at.
These people rarely if ever tell their colleagues and their boss what they REALLY think.
And probably don't tell themselves what they think of themselves either...brrrr.
As I mostly avoid "news" it's been a while since I saw a recent Trump pic.
He seems to have deteriorated quite a bit.
The people standing near him made me laugh out loud. Hilarious.
Just look at their postures and their faces and what/who they are looking at.
These people rarely if ever tell their colleagues and their boss what they REALLY think.
And probably don't tell themselves what they think of themselves either...brrrr.
Upvote
0
(0
/
0)