The insane abrasiveness of lunar dust is the biggest thing that proponents of lunar resource utilization tend to completely gloss over. On top of that, many particles of lunar dust are microscopic. Any sort of machinery without the best of seals is going to wear out the moving bits in short order. I'm not sure there is a good terrestrial analog for this as such a thing would most definitely be classified as an extremely hazardous material (silicosis anyone?).
I spent a lot of years working on the Space Station for Boeing. At one point, a number of us were tasked with looking at using space-station type modules on the Moon. The basic reason was our Space Station project would eventually run out of hardware to deliver, and the management wanted sell more of them on another project.
Turns out we didn't have to modify the modules much to use them on the Moon. We built and tested them on Earth in 1g, and were designed to work in 0-g, so 1/6g was not a problem. We rated lunar dust as the #1 problem that needed to be worked on. We came up with a number of possible approaches, but NASA wasn't going to pay us to actually do the R&D and figure out which ones would work best. Off the top of my head, they included:
* Paving landing pads and roads using concentrated sunlight to melt the lunar soil
* Lunar dust has a lot of glassy bits formed during impacts. Those bits hold an electrostatic charge, which is why the dust sticks to everything. Vacuum and dry soil allow static build-up from walking and driving. Even exposure to the Sun can charge up soil particles, which then repel each other (floating dust). So one approach is electrostatic wands, "lightning rods" and grounding wires, to dissipate the charges.
* A pre-airlock that you can pressurize a little and add humidity so the static charges can leak off, then blowers and suction to clean off the suits and equipment
* Suit-hatches (actually in current plans). The EVA suit never comes inside. You back up to a hatch interface, lock in, then climb out of a hatch in the back of the suit.
There are probably more ideas I can't remember any more, it was many years ago.