Anti-vaccine groups melt down over reports RFK Jr. to link autism to Tylenol

numerobis

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The problem with Vitamin D in particular is that it is bloody cheap. £8 at Amazon for a 13 times overdose every day for a month, or £96 for a 13 times overdose for a whole year. (12 packs of 400 tablets).

13 times the maximum recommended dose of anything will hurt you. 13 times the recommended dose of salt will kill you. 13 times the recommended dose of water will kill you three or four times over. 13 McDonald’s burgers with 13 portions of chips will make you utterly sick; do it for a month and you will have health consequences.
Lots of things are very cheap. The problem is the packaging.
 
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ranthog

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Lots of things are very cheap. The problem is the packaging.
The problem isn't packaging, but that we don't treat vitamin supplements as medicines. You don't know you're getting what is on the label. Then it is pushed by supplement companies in ways that are dangerous to sell more product.

On top of that, if some of these were packaged in blister packs of 12, they'd still be dangerous. Some of the stuff being sold, a single daily dose for long term can be toxic by themselves (primarily some of the fat soluble ones) or are hard on your other organs to remove them from the body.

If people were taking supplements based on doctor and pharmacist recommendations, and they were based on rational medical reasons it wouldn't be a problem.
 
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numerobis

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The problem isn't packaging, but that we don't treat vitamin supplements as medicines. You don't know you're getting what is on the label. Then it is pushed by supplement companies in ways that are dangerous to sell more product.

On top of that, if some of these were packaged in blister packs of 12, they'd still be dangerous. Some of the stuff being sold, a single daily dose for long term can be toxic by themselves (primarily some of the fat soluble ones) or are hard on your other organs to remove them from the body.

If people were taking supplements based on doctor and pharmacist recommendations, and they were based on rational medical reasons it wouldn't be a problem.
The problem as described is very much packaging. The tablets claim to contain 4,000 units. A usual daily dose is 1,000 units unless prescribed more (which would be based on a vitamin D deficiency). They're packaging a dangerously high dose.

If in addition the pills don't actually contain what they claim to contain that's a separate problem. As is the separate problem of drug interactions.
 
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ranthog

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The problem as described is very much packaging. The tablets claim to contain 4,000 units. A usual daily dose is 1,000 units unless prescribed more (which would be based on a vitamin D deficiency). They're packaging a dangerously high dose.

If in addition the pills don't actually contain what they claim to contain that's a separate problem. As is the separate problem of drug interactions.
Just because usage directions are printed on the packaging, doesn't mean they're a packaging problem. If the directions said to take four 1000 mg tablets daily (and there are supplements like calcium that have therapeutic doses that require multiple tablets), it would be the same problem as directions to take one 4000 mg tablet.

The dose in a tablet is based on the directions for use and the feasibility for having that much of the substance in the tablet. So if the only correct dose is 4000mg, then it is ideal to have people take a single 4000 mg tablet. Having people have to count out tablets potentially introduces errors.

Improper use directions is its own problem.

Packaging problems relate to things like medicine safety. For instance, if a medicine is only for short term use, then it should be sold in quantities that reflect that. So if you shouldn't use a medicine OTC for more than a week, you shouldn't sell a bottle with over a year's worth of medicine in it. Blister packs are used to make it harder to overdose or abuse a medication.

For instance, having a bottle with a thousand tasty vitamin gummies with a non-child proof cap is a packaging problem.
 
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Nilt

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The problem with Vitamin D in particular is that it is bloody cheap. £8 at Amazon for a 13 times overdose every day for a month, or £96 for a 13 times overdose for a whole year. (12 packs of 400 tablets).

13 times the maximum recommended dose of anything will hurt you. 13 times the recommended dose of salt will kill you. 13 times the recommended dose of water will kill you three or four times over. 13 McDonald’s burgers with 13 portions of chips will make you utterly sick; do it for a month and you will have health consequences.
Yeah, most of the "standard" vitamins are pretty darned cheap if they're sold as a standalone one. My aunt needs B12 and I got her a year supply and change at Costco for $10. I'm not sure what the max dosage on that is but I'd bet it's a lot less than the full bottle.
 
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Zeppos

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Wait wait. Hear me out, conspiracists.

I'm betting most of these Tylenol victims were also the victims of vaccinations. my guess is that some terrifying synergy between acetaminophen and thimerosal (sure, they were supposed to remove it from most vaccines... But did they?) results in the compound acetathimerosaphenol which triggers latent epigenetic autism that was placed in the human genome by demon consorts in the 1500s.

acetathimerosaphenol syndrome - you heard it here first, on ars technica, so you know it's good.

You can totally have your cake and eat it too.
This makes sense! I mean, you can have a bit of malaise after a vaccine. You take Tylenol to get through the day and bang, your baby has autism! My god! We have got to stop this! RFK?? RFK!!!
911 what is your emergency? Get me RFK on the line!
 
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ScifiGeek

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I wondered about a potential connection to Fever, since that would be something you might use Tylenol for during pregnancy. This is the first study I found.

https://www.nature.com/articles/mp2017119

One section was of particular interest:

Fever-associated risk stratified on use of antipyretics​

In secondary stratified analyses, we examined whether use of acetaminophen for fever modified fever-associated ASD risk. Risk tended to be lower within each trimester in febrile women who took acetaminophen for fever than in febrile women who did not (compared to the referent group of afebrile women; Supplementary Table S6A). The risk was similar both for women febrile in the second trimester who did and who did not specifically report taking acetaminophen for fever.

So in the case of Fever, Tylenol may actually lower the risk of Autism as it lowers fever.
 
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RZetopan

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It doesn’t really. Believing things that are obviously false isn’t at all correlated with the ability to work hard, and it’s not much correlated with intelligence.
Sure thing, and that is why so many members of the NAS are actually creationists. I said nothing about "working hard" since some creationists actually do the work to get a degree, but then they ignore the very core of their degree to peddle garbage. It does require a special kind of "intelligence" to believe the terminally counterfactual. From Wikipedia: "Intelligent design is a pseudoscientific argument for the existence of God, presented by its proponents as "an evidence-based scientific theory about life's origins". Proponents claim that "certain features of the universe and of living things are best explained by an intelligent cause, not an undirected process such as natural selection." ID is a form of creationism that lacks empirical support and offers no testable or tenable hypotheses, and is therefore not science." Feel free to show the "intelligence" in creationism.
 
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Tobold

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There probably will be history books about this century. It's just that most of them will not be written in English, nor published in North America.
If the Aussies write about our downfall, it will still be in English. And on the bright side, the Aussies might be the only ones with enough swears in their vocabulary for this stupidity.
 
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numerobis

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If the Aussies write about our downfall, it will still be in English. And on the bright side, the Aussies might be the only ones with enough swears in their vocabulary for this stupidity.
Equally true if it's Indians who inherit global leadership, which is rather more likely than an Australian hegemony.
 
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EvolvedMonkey

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Did you take special classes in school? Your statement is indicative of a dishonest person who pretends to have been born yesterday so they can pretend Republicans making every little thing "political" for decades is something that never occurred before.
I’m not sure how my lamenting the political destruction of any hope for autism management and treatment for the next generation managed to be seen as a positive statement supporting the people doing the destruction?

I am a fan of the republicans the same way the character AM was a fan of humanity.
 
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EvolvedMonkey

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I'm not arguing here; I just don't understand the reference. What is "the character AM"?
Apologies: character from the Harlan Ellison short story, I Have no Mouth and I Must Scream. Famous for his verbosity in regards to his hatred for humanity.

Best metaphor I have in me for how I feel when someone tries to call me a Republican on Ars.
 
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EnPeaSea

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Apologies: character from the Harlan Ellison short story, I Have no Mouth and I Must Scream. Famous for his verbosity in regards to his hatred for humanity.

Best metaphor I have in me for how I feel when someone tries to call me a Republican on Ars.
Ah! Right, my brain just wasn't connecting it and it's too late to blame too much blood in my caffeine stream.
 
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Pooga

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Started this when the article was only a couple days old, but got distracted before posting. Decided (probably incorrectly) it was still worth sharing...
I'm reminded of the Babylon 5 episode The Deconstruction of Falling Stars (the S4 finale) where a few hundred years after the main time frame of the series, the main characters are shown as illustrated characters in a book created in a monastery (after Earth got its ass handed to it during a war a few hundred years earlier, it's still recovering and hand-illustrated books appear to be state of the art in knowledge recording, at least among the regular residents of Earth.)
Good show, great episode and scene, but that part was totally a rip-off of/homage to the classic sci-fi story A Canticle for Leibowitz.
 
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charltjr

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A note:

Most people who end up with accidental acetaminophen toxicity weren't popping them like M&Ms, most were taking 3 different medicines that all contain it.

It's easy: Tylenol contains Tylenol. If that's not working? Take a Vicodin. Which also contains Tylenol. And NyQuil also has it.

There have definitely been some influenza days where if I hadn't known not to already, I'd 100% have done that.

I mean, it's crazy that the safest recommended daily intake (~4000mg) is so close to the OMG aren't liver transplants fun level (~12000mg) but 12g of acetaminophen is a lot. (~30+ "extra strength" Tylenol tablets all at once)

This is why in many jurisdictions Tylenol is individually blistered for retail sale.

That's scary. In the UK everything that contains Paracetamol is clearly marked as containing Paracetamol for exactly that reason. Same with other over the counter painkillers like Ibuprofen.
 
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